Yay new podcasts! My fiance and I have radically different tastes in music so we listen to a LOT of podcats in the car.
No Such Thing as a Fish is the podcast from the British comedy trivia show QI (MY FAVORITE)
My Brother My Brother and Me is a comedy ?advice show, they address nonsensical Yahoo! Answers questions
Sawbones is one of the guys from My Brother and his wife, she's a doctor and they talk about weird medical stuff from history.
Oh No with Ross and Carrie investigates different religions in a respectful open-minded way. They go to meetings/services and explore. I like it because they are honest about their impressions of the culture without going into the beliefs themselves, at least without judgement.
The Naked Scientists talk about offbeat science
Pop Culture Happy Hour is what it sounds like, from NPR
Wait Wait Don't Tell Me, well it's my favorite NPR show (comedy current events quiz) but it's available in podcast format. I recommend the NPR One app for any public radio types, it basically has the last week of content, searchable and skippable. I usually stream in my car from my phone.